Oligo Modification By Application
May 4, 2026 by Dawn Lam
Circular oligonucleotides are an emerging class of nucleic acid therapeutics (NATs) because of their resistance to exonucleases and their reduced immunogenicity.[1] Wesselhoeft et al., demonstrated that exogenous circRNA did not activate Toll-like Receptors (TLRs) nor Retinoic acid-Inducible Gene I (RIG-I), provided that the circRNA was meticulously purified to remove all linear RNA fragments. In addition, […]
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