Therapeutic Oligos

From in silico design to custom oligo synthesis and in vitro screening, we provide a seamless, end-to-end solution under one roof.

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Overview

Synoligo supports oligonucleotide discovery from in silico design through lead identification and optimization. With integrated capabilities in sequence selection, complex oligo synthesis, and high-throughput in vitro screening, we help teams move from concept to validated candidates with greater efficiency and confidence.

Stages We Cover

Explore our comprehensive solutions tailored for the development, manufacturing and testing of oligonucleotides from research to preclinical stage.

In Silico Design

What We Offer

Smart sequence selection powered by advanced design strategies to identify high-potential oligo candidates early. We prioritize efficacy, specificity, and developability from the start.

Design support for a broad range of oligonucleotide modalities:

siRNA
ASO and gapmer oligos
Splice-switching oligos

Platform Workflow

Target Transcript Analysis

Transcript variant alignment and selection
SNP Analysis
Expression profile

Sequence Design

Hits identification and mapping
Thermodynamic properties
Species cross-reactivity analysis

Off-Target Prediction

Near-perfect-match off-target genes identification
Seed mediated off-target genes identification

Library Design

Initial sequence selection for library generation
Chemical modification design

Gene Editing

CRISPR/sgRNA: cas9, cas12a

pegRNA: prime editing up to 200mer

RNA Editing

Gene Expression/ Upregulation or Silencing

ASO fully modified or conjugated

PMO: peptide or antibody conjugated

siRNA/miRNA/saRNA: click & maleimide chemistry ready

Protein Expression

mRNA, self-amplifying RNA, circular mRNA

Molecular Targeting

Aptamer: DNA-, RNA-, TNA-, Speigelmer-based, PEGylated, bispecific

Hepatic and Extrahepatic Delivery

XOC: Peptide, protein, antibody, small molecule conjugated

Other Oligos

Immunostimulatory agents: CpG1018, CpG7909, 5′-di- and 5′-triphosphate

Custom Synthesis

What We Manufacture

From small research batches to high-throughput production for lead selection and scalable synthesis to support preclinical studies, Synoligo delivers consistent quality at every stage.

In Vitro Screening

Assays We Support

High-throughput screening workflows to evaluate potency, toxicity, and delivery performance across relevant cell models.

Potency Screening

RT-qPCR based screening
Luciferase reporter assay
Protein based assay

Off-Target Assessment

High-throughput RNA extraction & RNA sequencing

Cytotoxicity Assay

Cell titer Glo Assay
Caspase-Glo 3/7 Assay
LDH Assay

Why a One-Stop Shop Matters:

End-to-End Support

Fewer Handoffs for a
Seamless Process

Quick Data for Go/No-Go
Decisions

Fastest Path to Lead
Optimization

Request Quote

Send us your sequences and questions and we’ll get you a tailored quote fast.

Case Studies

Proof in the data. Browse screening results we’ve generated in-house.

Bundle & Save!

For a first time customer discount - bundle ASO Library & In Vitro screening!

Applications of Oligos

With decades of experience, our expert team specializes in manufacturing oligos tailored to diverse scientific applications, ensuring your specific needs are met.

Research Oligos

Extensive list of customization allows researchers to achieve their research goals.

Branched/dendrimer
Circular DNA/RNA
Ultra-long oligos (150–200nt)
DNA-encoded library (DEL)

Diagnostic Oligos

Broad selection of various dyes and probes

Primers PCR/qPCR
FISH/MERFISH Probes
FRET Probes
NGS Adapters
Molecular Beacons