Explore one of the most extensive oligo modification libraries in the industry. This list reflects the broad range of chemical modifications we routinely support for custom oligo synthesis, designed to meet diverse research, diagnostic and therapeutic needs.

Trademarks & Disclaimers:

All product and brand names mentioned are trademarks or registered trademarks of their respective holders.
Alexa Fluor® dyes are registered trademarks of Molecular Probes, Inc.
ATTO™ Dyes are registered trademarks of ATTO Technology Inc.
Black Hole Quencher®, BHQ-1®, BHQ-2®, BHQ-dT®,and Quasar® are registered trademarks of Biosearch Technologies, Inc.
Cy3®, Cy5®, and Cy5.5® are registered trademarks of GE Healthcare.
FAM™, HEX™, ROX™, TAMRA™, JOE™, NED™ and VIC™ are trademarks of Applied Biosystems, a brand of Thermo Fisher Scientific.
LNA® is registered trademark of Exiqon A/S.
MGB™ is a trademark of Epoch Biosciences.
IRDye is a registered trademark of Li-COR Biosciences.
Eclipse™ Quencher and Super T are registered trademarks of ElitechGroup, Inc.
SNAP-tag® is a registered trademark of New England Biolabs, Inc
HaloTag® is a registered trademark of Promega Corporation.
Acrydite® is a registered trademark of Mosaic Technologies Corp.
MSD Tag® is a registered trademark of Meso Scale Diagnostics LLC.

Notes:

• All codes need to be in a parenthesis, except A, C, G, T (for DNA), rA, rC, rG, rU (for RNA), mA, mC, mG, mU (for 2′-OMe), and fA, fC, fG, fU (for 2′-F). For example: (LNA-A)AmC fGrU(dU) (mT)*(moeA)(cetG) (FANA-C)(GNA-A)(fAs)* (5Me-dC)(G-Mesyl)A
• The default backbone linkage between two modification codes is phosphodiester, except * for phosphorothioate and dithiophosphate, e.g., GCT (dAs)*C*G* TCA and ^ for linkage made by post-synthesis conjugation, e.g., (TCO-N)^(C6NH2)A CGT.
• The default backbone linkage between two modification codes is phosphodiester, except * for phosphorothioate and dithiophosphate, e.g., GCT (dAs)*C*G* TCA and ^ for linkage made by post-synthesis conjugation, e.g., (TCO-N)^(C6NH2)A CGT.
• Other symbols representing backbone modifications that can be used in the sequence are:
• Other symbols representing backbone modifications that can be used in the sequence are:
  • Butyl is & e.g. (dA)&C&G
  • Mesyl is # e.g. (dA)#C#G
  • PN1 is $ e.g. (dA)$C$G
  • ¹⁸O is £ e.g. (dA)C£G£
  • ³⁴S is ¥ e.g. (dA)C¥G¥
• This table never includes Customer proprietary codes. If you are the owner of a code, feel free to use it in the sequence.
• New Mod is added regularly. If you don’t see the Mod code you need, please let us know by email at oligosales@synoligo.com.