Oligo Modification By Application
May 4, 2026 / May 5, 2026 by Dawn Lam
Circular oligonucleotides are an emerging class of nucleic acid therapeutics (NATs) because of their resistance to exonucleases and their reduced immunogenicity.[1] Wesselhoeft et al., demonstrated that exogenous circRNA did not activate Toll-like Receptors (TLRs) nor Retinoic acid-Inducible Gene I (RIG-I), provided that the circRNA was meticulously purified to remove all linear RNA fragments. In addition, […]
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