Oligo Modification By Application
September 18, 2025 / September 19, 2025 by Dawn Lam
Antibodies have unique targeting specificity for different cell- and tissue-types. This has led to rapid growth in Antibody-Drug Conjugates (ADCs) for the treatment of cancer, which can deliver a cytotoxic payload to a particular cell-type or to cancerous cells that overexpress specific receptors. Oligonucleotides, such as antisense oligos (ASOs) and small-interfering RNA oligos (siRNAs), have […]
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August 14, 2025 / October 2, 2025 by Dawn Lam
In their nucleic acid base sequences, RNA and DNA encode the sequences of amino acids that make up proteins. In cells with nuclei (including human cells) RNA is copied from DNA in the nucleus and the RNA is exported to the cytoplasm, where it binds to ribosomes. A ribosome uses the information in an RNA […]
May 16, 2025 / September 8, 2025 by Dawn Lam
Background Lanthanides are photoluminescent metals that are characterized by very sharp and narrow emission bands and very long emission lifetimes arising from 4f orbital transitions. These long lifetimes can be used to essentially eliminate background fluorescence by using time-resolved spectroscopy since lifetimes of fluorophores and fluorescent compounds are on the nanosecond time scales where lanthanides […]
Oligo Modification By Application RNA Modification
February 13, 2025 / February 27, 2025 by Dawn Lam
A recent paper by Wave Life Sciences1 describes a new application of isouridine (N3U) for improving the efficiency of ADAR-assisted editing of mRNA in a disease-relevant target. Background ADARs (Adenosine Deaminase Acting on RNA) are endogenous enzymes that are found in all vertebrates. In humans ADAR1 and ADAR2 bind dsRNA and perform A-to-I edits at […]
Oligo Modification By Application Spatial Transcriptomics
October 11, 2024 / February 5, 2025 by Dawn Lam
What is Spatial Transcriptomics? Spatial transcriptomics is a cutting-edge technology that allows researchers to study gene expression profiles of cells while maintaining their location within a tissue. This method has become popular in fields like oncology, neurobiology, and developmental biology due to its ability to map gene expression at single-cell resolution. By preserving tissue architecture, […]
CRISPR Oligo Modification By Application
June 5, 2024 / February 5, 2025 by Dawn Lam
What is CRISPR Technology? CRISPR/CasX Technology (Clustered Regularly Interspaced Short Palindromic Repeats), derived from bacteria, has been a cornerstone of genetic engineering in the therapeutic industry for decades. The technology is versatile with its application, spanning across various fields, from agriculture to medicine, and enabling scientists to modify DNA sequences with remarkable accuracy. The most […]
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