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August 6, 2026 by Dawn Lam
Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), act through base pairing between a short sequence and a target transcript. Although sequences can be selected that perfectly match only the intended target, partial complementarity to other transcripts can cause off-target effects (Figure 1). These hybridization-dependent off-target effects have been well established for […]
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