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August 31, 2026 by Dawn Lam
Introduction Nucleic Acid Therapeutics (NATs), including antisense oligonucleotides (ASOs), splice-switching oligos, siRNAs and their conjugates act inside cells in tissue, not in plasma, so interpreting their pharmacology depends on measuring tissue concentrations of the intact drug in the presence of chain-shortened metabolites. This review covers the hybridization assay formats in current use, the chemistry that […]
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