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October 6, 2026 by Dawn Lam
Introduction The clinical success of GalNAc-conjugated siRNAs established a powerful paradigm for nucleic acid therapeutics (NATs): effective delivery through receptor-mediated endocytosis (RME) can transform a promising nucleic acid into a viable medicine. GalNAc succeeded because it leveraged the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes and undergoes efficient receptor recycling. As a result, […]
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