Oligo Modification By Property
November 12, 2025 / November 17, 2025 by Dawn Lam
In a recent Blog Post entitled, Using Stable Isotope Labeling with 34S for Pharmacokinetic and Biodistribution Studies, the advantages of using stable isotopic labels (SIL) to generate an internal standard was discussed. Summary of SIL: We would be remiss not to also mention another isotope amenable to labeling oligonucleotides – 18O. Like 34S, the isotopic […]
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November 6, 2025 / November 12, 2025 by Dawn Lam
If you go to https://clinicaltrials.gov/ and search “oligonucleotide” as the treatment, you’ll come up with over 260 trials which covers a variety of types of therapeutics modalities – ASOs, siRNAs, sgRNAs, and aptamers-most of which contain phosphorothioate linkages in the backbone. The reason for this is two-fold. First, the phosphorothioate linkages (PS) substantially increase nuclease […]
Oligo Modification By Property Stability
January 4, 2025 / February 11, 2025 by Dawn Lam
What are some current nuclease resistance modifications that are being used? Oligonucleotides are susceptible to enzymatic degradation by exonucleases and endonucleases, particularly RNA, which is prone to both chemical instability and rapid breakdown. These challenges can significantly shorten their half-life and limit their effectiveness. To counteract these issues, various chemical modifications can be incorporated to improve […]
Oligo Modification By Property Quality Control
July 10, 2024 / February 5, 2025 by Dawn Lam
What are endotoxins? Endotoxins, also known as lipopolysaccharides (LPS), are toxins produced by Gram-negative bacteria. They are released when the bacteria are killed or undergo cell lysis. LPS consists of three parts: lipid A, core polysaccharide, and O antigen. Lipid A is the toxic component responsible for triggering inflammatory and immune responses in mammals. Symptoms can vary […]
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