Backbone Oligo Modification by Type
November 22, 2024 / February 2, 2025 by Dawn Lam
Check out our updated section below! What are antisense oligonucleotides (ASOs)? Antisense oligonucleotides (ASOs) are short nucleic acids designed to bind to specific RNA sequences, thereby inhibiting, reducing, restoring, or modifying the expression of target RNA. Over the past two decades, this method of gene silencing at the posttranscriptional stage has become increasingly popular as […]
Read more »
5' Terminal Caps Oligo Modification by Type
September 18, 2024 / February 2, 2025 by Dawn Lam
What are 5′ triphosphate oligonucleotides and how are they being used? 5′ triphosphate (5′-PPP) oligonucleotides are short strands of nucleic acids with a triphosphate group attached to their 5′ end (Image 1). This 5′-triphosphate plays crucial roles in biological processes, particularly in RNA biology. Incorporating 5′-PPP into RNA or DNA oligos enables a variety of […]
Oligo Modification by Type Sugar
May 6, 2024 / February 2, 2025 by Dawn Lam
Why is Threose Nucleic Acid (TNA) modification being used? The use of oligonucleotides in therapeutics and diagnostics is rapidly expanding, particularly in the realm of antisense therapy. In previous discussions, we explored how modifying the backbone of antisense oligonucleotides (ASOs) with Mesyl can enhance stability and therapeutic efficacy. In this blog, we shift our focus to a […]
Get access to technical content, promotions, upcoming events and press release.
