Backbone Oligo Modification by Type
November 22, 2024 / February 10, 2025 by Dawn Lam
What backbone chemistries have been used for stereopure oligonucleotides? Traditional oligonucleotide synthesis using standard phosphoramidite methods does not control stereochemistry, resulting in a stereorandom phosphorothioate (PS) mixture where each linkage may adopt either R or S configuration. Studies in retinal disorders, CNS diseases, and muscular atrophy have demonstrated that stereopure oligonucleotides can significantly impact biological […]
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