Oligo Modification By Property

Using 18O as a Stable Isotopic Label (SIL) in Therapeutic Oligonucleotides containing Phosphodiester Linkages

November 12, 2025 / November 17, 2025 by Dawn Lam

In a recent Blog Post entitled, Using Stable Isotope Labeling with 34S for Pharmacokinetic and Biodistribution Studies, the advantages of using stable isotopic labels (SIL) to generate an internal standard was discussed.  Summary of SIL: We would be remiss not to also mention another isotope amenable to labeling oligonucleotides – 18O.  Like 34S, the isotopic […]

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Oligo Modification By Property

Using Stable Isotope Labeling with 34S for Pharmacokinetic and Biodistribution Studies

November 6, 2025 / November 12, 2025 by Dawn Lam

If you go to https://clinicaltrials.gov/ and search “oligonucleotide” as the treatment, you’ll come up with over 260 trials which covers a variety of types of therapeutics modalities – ASOs, siRNAs, sgRNAs, and aptamers-most of which contain phosphorothioate linkages in the backbone. The reason for this is two-fold.  First, the phosphorothioate linkages (PS) substantially increase nuclease […]

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