Oligo Modification By Property Stability
January 4, 2025 / January 6, 2025 by Dawn Lam
What are some current nuclease resistance modifications that are being used? Oligonucleotides are susceptible to enzymatic degradation by exonucleases and endonucleases, particularly RNA, which is prone to both chemical instability and rapid breakdown. These challenges can significantly shorten their half-life and limit their effectiveness. To counteract these issues, various chemical modifications can be incorporated to improve […]
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