Industry Insights
October 27, 2026 by Dawn Lam
A forward-looking perspective on confining escape enhancement to the target cell and the intracellular trigger For every oligonucleotide modality now in the clinic, the rate-limiting step is not cell entry. Uptake is comparatively easy: phosphorothioate ASOs bind cell-surface and serum proteins and are taken up gymnotically, GalNAc conjugates are cleared into hepatocytes within minutes by […]
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