Oligo Modification By Property

Using Stable Isotope Labeling with 34S for Pharmacokinetic and Biodistribution Studies

November 6, 2025 / November 12, 2025 by Dawn Lam

If you go to https://clinicaltrials.gov/ and search “oligonucleotide” as the treatment, you’ll come up with over 260 trials which covers a variety of types of therapeutics modalities – ASOs, siRNAs, sgRNAs, and aptamers-most of which contain phosphorothioate linkages in the backbone. The reason for this is two-fold.  First, the phosphorothioate linkages (PS) substantially increase nuclease […]

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