Backbone Oligo Modification by Type
November 22, 2024 / December 20, 2024 by Dawn Lam
What backbone chemistries have been used for stereopure oligonucleotides? Traditional oligonucleotide synthesis using standard phosphoramidite methods does not control stereochemistry, resulting in a stereorandom phosphorothioate (PS) mixture where each linkage may adopt either R or S configuration. Studies in retinal disorders, CNS diseases, and muscular atrophy have demonstrated that stereopure oligonucleotides can significantly impact biological […]
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May 6, 2024 / December 20, 2024 by Dawn Lam
Check out our updated section below! What are antisense oligonucleotides (ASOs)? Antisense oligonucleotides (ASOs) are short nucleic acids designed to bind to specific RNA sequences, thereby inhibiting, reducing, restoring, or modifying the expression of target RNA. Over the past two decades, this method of gene silencing at the posttranscriptional stage has become increasingly popular as […]
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