Oligo Modification By Application

An Introduction to Splice-Switching Oligonucleotides

January 6, 2026 / January 6, 2026 by Dawn Lam

In 1977, the laboratories of Richard Roberts and Phillip Sharp independently discovered that the DNA sequences of genes were substantially longer than their respective mRNAs.  This led to the discovery of introns and exons, the names coined by Walter Gilbert in 1978 for these ‘intragenic regions’ and ‘expressed regions’ respectively.  Gilbert theorized that splicing allowed […]

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