Oligo Modification By Application

The Use of Ligases in the Convergent Synthesis of Nucleic Acids

March 23, 2026 / March 23, 2026 by Dawn Lam

Background Ligases are ubiquitous.  They are found in every living organism and are required for cell division – stitching together the Okazaki fragments produced during DNA replication and maintaining genetic integrity by performing the final step in every DNA repair pathway – the crucial ligation step – which is the formation of a phosphodiester linkage […]

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