Oligo Modification By Application

Site-Specific Enzymatic Labeling of Native Monoclonal Antibodies

January 29, 2026 / January 30, 2026 by Dawn Lam

Monoclonal antibodies provide exquisite targeting specificity for different cell types, markers and cell-surface receptors. When conjugated to therapeutic oligos, such as siRNAs and antisense oligos, the antibody facilitates the internalization of the therapeutic oligo by receptor-mediated endocytosis. In a previous article Choosing Linkers for Antibody-Oligonucleotide Conjugates (AOCs) versus for Antibody-Drug Conjugates (ADCs), we focused on […]

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