Oligo Modification By Application RNA Modification
February 13, 2025 / February 27, 2025 by Dawn Lam
A recent paper by Wave Life Sciences1 describes a new application of isouridine (N3U) for improving the efficiency of ADAR-assisted editing of mRNA in a disease-relevant target. Background ADARs (Adenosine Deaminase Acting on RNA) are endogenous enzymes that are found in all vertebrates. In humans ADAR1 and ADAR2 bind dsRNA and perform A-to-I edits at […]
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